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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. After the first intravenous bolus dose of a drug, the peak concentration is 50 mcg/mL, the elimination rate constant is 0.3/h, and the dosage Interval is 6 hours. Assuming a one compartment model and intravenous bolus injection, which of the following will be the peak concentration following the second dose?

A) 64 mcg/mL
B) 75 mcg/mL
C) 50mcg/mL
D) 58 mcg/mL

2. Which of the following disease states has been associated with stress-related mucosal bleeding and is an indication for initiation of stress ulcer prophylaxis?

A) Gastric carcinoma
B) Diabetes mellitus
C) Coagulopathy
D) Ulcerative Colitis

3. A 59-year-old man presents to the neurology clinic with recently diagnosed Parkinson's disease.
At his last visit 2 months ago, selegiline therapy was instituted, and he is tolerating it well. The patient still complains of tremor and rigidity that are interfering with both professional and leisure activities. Which option is most appropriate at this time?

A) Change to entacapone.
B) Change to ropinirole.
C) Change to amantadine.
D) Change to carbidopa/levodopa.

4. The results of a drug-use evaluation study by the P & T Committee reveal that 15 prescribers are using an antibiotic inappropriately. Which of the following is the most effective strategy for improving the drug therapy?

A) Sending the prescriber's a letter with the results of the study and educational material
B) Meeting in a seminar with the prescribers to review the results of the study
C) Including the results of the study and educational material in a newsletter distributed to the medical staff
D) Meeting individually with the prescribers to review the results of the study and review educational material

5. A 25-year-old man who weighs 80 kg is brought to the emergency department following a motor vehicle collision. He has severe facial contusions and a presumed closed head injury. His Glasgow Coma Scale score is 8. An emergency CT scan shows no evidence of intracranial bleeding. What should recommendations for therapy include?

A) Diazepam 5 mg intravenously over 5 minutes, qh6 for one week
B) Dexamethasone 10 mg intravenously q6h for one week
C) Phenytoin 1,200 mg intravenously over 45 minutes, then an appropriate maintenance dose for one week
D) Fosphenytoin 25 PE/kg intravenous push, then an appropriate maintenance dose for one week

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